Canalisation (canalization in American English) is a measure of the ability of a population to produce the same phenotype regardless of variability of its environment or genotype. In other words, it means robustness. The term canalisation was coined by C. H. Waddington.[1] He used this word rather than robustness to take into account that biological systems are not robust in the quite the same way as, for example, engineered systems. Biological robustness or canalisation comes about when developmental pathways are shaped by evolution. Waddington introduced the epigenetic landscape, in which the state of an organism rolls "downhill" during development. In this metaphor, a canalised trait is illustrated as a valley enclosed by high ridges, safely guiding the phenotype to its "fate". Waddington claimed that canals form in the epigenetic landscape during evolution, and that this heuristic is useful for understanding the unique qualities of biological robustness.[2]
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Waddington used the concept of canalisation to explain his experiments on genetic assimilation.[3] In these experiments, he exposed Drosophila pupae to heat shock. This environmental disturbance caused some flies to develop a crossveinless phenotype. He then selected for crossveinless. Eventually, the crossveinless phenotype appeared even without heat shock. Through this process of genetic assimilation, an environmental induced phenotype had become inherited. Waddington explained this as the formation of a new canal in the epigenetic landscape.
It is, however, possible to explain this observation of genetic assimilation using only quantitative genetics and a threshold model, with no reference to the concept of canalisation.[4][5][6][7] However, theoretical models that incorporate a complex genotype-phenotype map have found evidence for the evolution of phenotypic robustness[8] contributing to genetic assimilation,[9] even when selection is only for developmental stability and not for a particular phenotype, and so the quantitative genetics models do not apply. These studies suggest that the canalisation heuristic may still be useful, beyond the more simple concept of robustness.
Neither canalisation nor robustness are simple quantities to quantify: it is always necessary to specify which trait is canalised/robust to which perturbations. For example, perturbations can come either from the environment or from mutations. It has been suggested that different perturbations have congruent effects on development taking place on an epigenetic landscape.[10][11][12][13][14] This could, however, depend on the molecular mechanism responsible for robustness, and be different in different cases.[15]
The canalisation metaphor suggests that phenotypes are very robust to small perturbations, for which development does not exit the canal, and rapidly returns back down, with little effect on the final outcome of development. But perturbations whose magnitude exceeds a certain threshold will break out of the canal, moving the developmental process into uncharted territory. Strong robustness up to a limit, with little robustness beyond, is a pattern that could increase evolvability in a fluctuating environment.[16] Genetic canalization could allow for evolutionary capacitance, where genetic diversity outside the canal accumulates in a population over time, sheltered from natural selection because it does not normally affect phenotypes. This hidden diversity could then be unleashed by extreme changes in the environment or by molecular switches, releasing previously cryptic genetic variation that can then contribute to a rapid burst of evolution.
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